CLOSTRIDIUM DIFFICILE BINARY TOXIN A/B BY PCR

The CLOSTRIDIUM DIFFICILE BINARY TOXIN A/B BY PCR test detects the presence of genes encoding the binary toxin (cdtA and cdtB) of Clostridioides difficile using molecular PCR amplification from a patient stool specimen. By identifying genetic markers of the binary toxin, this assay helps distinguish toxigenic strains that are associated with more severe disease and higher recurrence risk, offering greater sensitivity than many conventional antigen or toxin immunoassays.

This test is used when a rapid, sensitive determination of a toxigenic C. difficile strain is needed to guide clinical management and infection-control decisions. It is appropriate for patients with new or worsening antibiotic-associated diarrhea, severe colitis, recurrent infections, recent hospitalization, or when an outbreak is suspected. Samples can be collected at home with Touch Connect’s lab-at-home service and processed in accredited Dubai/UAE laboratories; results are reported to the patient and treating clinician with interpretation advice and recommendations for follow-up where needed.

• Clostridium difficile binary toxin A gene (cdtA)
• Clostridium difficile binary toxin B gene (cdtB)
• Internal PCR control (sample adequacy)

• New-onset watery or severe antibiotic-associated diarrhea
• Recurrent C. difficile infection or relapse after treatment
• Severe colitis, bloody stools, or systemic signs of infection
• Recent hospitalisation or long-term care exposure with suspected transmission
• During suspected outbreak investigations in healthcare settings

• High sensitivity and specificity for binary-toxin–producing C. difficile strains
• Rapid molecular results to support timely treatment and infection control
• Convenient home stool collection with UAE-wide sample pickup and lab processing
• Clinician-ready reports that aid therapeutic decision-making and recurrence risk assessment
• Performed in accredited laboratories to meet Dubai/UAE regulatory standards

• Fresh stool sample collected in the provided sterile container
• Avoid contamination with urine or water; deliver sample promptly after collection
• No fasting required; continue usual medications and note recent antibiotic use
• Provide clinical history (symptoms, recent antibiotics, hospital stays) for accurate interpretation