IA2 Insulin Autoantibodies

The IA2 Insulin Autoantibodies test detects antibodies directed against the insulinoma-associated antigen-2 (IA‑2), a pancreatic beta‑cell protein. Performed by sensitive immunoassays on a blood sample, it identifies immune-mediated beta‑cell injury and is an important marker used to support the diagnosis of type 1 diabetes and related autoimmune forms of diabetes.

This test is useful for people with new‑onset hyperglycaemia, children or adolescents presenting with diabetic ketoacidosis, adults with atypical or rapidly progressive diabetes (including suspected LADA), and for risk assessment in first‑degree relatives. Results are reported as qualitative (positive/negative) and quantitative titres where available; interpretation should be done alongside clinical findings and other tests (e.g., GAD65 antibodies, C‑peptide). Home sample collection is available across Dubai and the UAE with processing in accredited labs, helping patients access timely diagnostic information without visiting a clinic.

• IA‑2 (IA2) Autoantibodies
• Antibody Titre (U/mL)
• Result (Positive / Negative)
• Laboratory Reference Range

• New‑onset hyperglycaemia where type 1 diabetes is suspected
• Children or adolescents presenting with DKA or rapid symptom onset
• Adults with lean phenotype or rapid progression to insulin dependence (possible LADA)
• First‑degree relatives of type 1 diabetes patients for risk assessment
• When clarifying diabetes classification before changing long‑term therapy

• Detects autoimmune markers indicating beta‑cell destruction
• Helps differentiate type 1 diabetes from type 2 and LADA
• Supports early treatment decisions, including timely insulin initiation
• Enables family risk counselling and targeted follow‑up testing
• Convenient at‑home blood collection with UAE‑accredited laboratory processing

• At‑home or clinic blood sample collection (venous preferred; capillary where supported)
• No fasting required prior to the test
• Suitable for adults and children; paediatric collection available on request
• Provide valid ID and clinical history; discuss any immunotherapies with your physician before testing