
Y Chromosome - Microdeletions
Author Details
Written By
Dr. Sameer Joshi
MD (Physician)
Supervised By
Dr. Imran Sheikh
MBBS, DNB





Y Chromosome - Microdeletions
Home-based Y chromosome microdeletions test providing accurate detection of male infertility-related genetic defects, with discreet sample collection and UAE-certified laboratory analysis.
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The Y chromosome microdeletions test is a home-based genetic analysis that detects deletions in key spermatogenesis regions (commonly AZFa, AZFb and AZFc) associated with male infertility, helping identify genetic causes of azoospermia or severe oligospermia. A discreet buccal swab or blood sample is collected at home and analysed by a UAE‑certified laboratory using PCR-based methods to provide sensitive and specific detection. It is recommended for men with abnormal semen parameters or those planning assisted reproduction, as results inform prognosis, guide treatment decisions and support referral for genetic counselling and specialist follow‑up.
Parameters Measured
- AZFa deletion — sY84, sY86
- AZFb deletion — sY127, sY134
- AZFc deletion — sY254, sY255
- SRY gene (sex-determining region Y)
- Internal PCR control (AMEL assay)
When to Test it?
- Comprehensive detection of AZFa, AZFb and AZFc Y chromosome microdeletions linked to male infertility
- Home-based, non‑invasive buccal swab kit with discreet UAE-compliant sample collection
- DNA analysis performed in a UAE-certified genetics laboratory with quality-controlled assays
- Clinical report detailing deletion status and implications for fertility treatments and reproductive options
- Rapid turnaround and optional genetic counselling referral from specialists in Dubai
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Benefits Includes:
- Sensitive PCR-based detection of Y-chromosome microdeletions in AZFa, AZFb and AZFc regions linked to male infertility
- Discreet home sample collection with trained technician pickup and UAE‑certified laboratory analysis
- Actionable report to support fertility counselling and assisted-reproduction decisions (e.g., ICSI or donor sperm considerations)
- Secure, confidential results with clear interpretation and recommended next steps from genetic specialists
- Rapid turnaround and full compliance with UAE regulatory and data‑protection standards
Doctor Recommended Checkups
Test requirements:
- Discreet at-home DNA collection kit with easy step-by-step instructions and secure sample return
- Sensitive PCR-based analysis detecting AZFa, AZFb and AZFc Y‑chromosome microdeletions linked to male infertility
- Processed in a UAE‑certified genetics laboratory with secure online results and a clear interpretive report for clinicians
- Recommended for men with azoospermia, severe oligospermia or recurrent ART failure; typical turnaround 7–14 business days
Author Details
Written By
Dr. Sameer Joshi
MD (Physician)
Supervised By
Dr. Imran Sheikh
MBBS, DNB

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