IMMUNOFIXATION ELECTROPHORESIS; URINE

Urine immunofixation electrophoresis (UIFE) is a laboratory technique that separates and identifies immunoglobulin heavy and light chains in urine to detect monoclonal proteins (M‑proteins) and free light chains. The test concentrates urinary proteins, separates them by electrophoresis, and then uses specific antisera to reveal monoclonal bands—valuable for diagnosing and monitoring conditions such as multiple myeloma, light‑chain disease, and AL amyloidosis. Performed on urine samples, UIFE is a sensitive, non‑invasive complement to serum testing and is commonly used when urinary protein excretion or unexplained renal impairment is suspected.

• IgG heavy chain
• IgA heavy chain
• IgM heavy chain
• Kappa light chains (urinary)
• Lambda light chains (urinary)
• Presence of monoclonal (M) protein / Bence Jones protein

• Suspected multiple myeloma or plasmacytic disorders
• Persistent unexplained proteinuria or rising urine protein levels
• Unexplained renal dysfunction suggesting light‑chain nephropathy
• Evaluation of suspected AL (light‑chain) amyloidosis
• Monitoring response or relapse in known monoclonal gammopathy

• High sensitivity for detecting monoclonal immunoglobulins and free light chains
• Non‑invasive urine sample suitable for home collection
• Useful for early detection and monitoring of multiple myeloma and related disorders
• Distinguishes monoclonal from polyclonal protein patterns to guide specialist referral
• Discreet home collection with certified laboratory reporting across Dubai and the UAE

• Preferable 24‑hour urine collection in the sterile container provided
• Keep collected urine refrigerated during the collection period and return promptly
• Label sample with patient name, collection start/end times, and contact details
• Inform the lab/clinician of current medications and any known monoclonal gammopathy