IMMUNOFIXATION, QUANTITATIVE (SERUM)

IMMUNOFIXATION, QUANTITATIVE (SERUM) is a laboratory test that identifies and quantifies monoclonal immunoglobulins (M‑proteins) in the blood by combining immunofixation electrophoresis with densitometric or reagent-based quantification. The assay determines immunoglobulin isotype (for example IgG, IgA, IgM) and associated light chain type (kappa or lambda), allowing precise measurement of abnormal protein concentrations in serum. This quantitative approach improves sensitivity over qualitative methods and supports diagnosis and ongoing management of monoclonal gammopathies.

The test is commonly used to detect and monitor conditions such as monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, Waldenström’s macroglobulinemia and related disorders, and to follow treatment response or relapse. Available with convenient home blood collection across Dubai, results are reported in standard clinical units and should be interpreted alongside clinical findings and other tests (e.g., serum protein electrophoresis, free light chain assay) by a hematologist or treating physician.

• Total serum M‑protein (quantitative)
• Immunoglobulin G (IgG) concentration
• Immunoglobulin A (IgA) concentration
• Immunoglobulin M (IgM) concentration
• Serum free light chains – Kappa and Lambda
• Immunofixation pattern / isotype identification (e.g., IgG kappa)

• Suspected multiple myeloma or other plasma cell dyscrasias
• Unexplained anemia, bone pain, hypercalcemia, or renal impairment
• Abnormal serum protein electrophoresis (SPEP) or elevated total protein
• Monitoring known monoclonal gammopathy for treatment response or relapse
• New peripheral neuropathy or recurrent unexplained infections with suspected immune protein abnormality

• Accurate identification of monoclonal immunoglobulin isotype
• Quantitative measurement for monitoring disease burden and therapy response
• Early detection of emerging monoclonal proteins to guide timely referral
• Convenient trained phlebotomist home collection across Dubai
• Laboratory reporting compatible with UAE clinical and specialist follow-up

• Venous blood sample collected at home by a trained phlebotomist
• No routine fasting required unless your physician instructs otherwise
• Provide recent clinical notes or prior SPEP/immunofixation reports for comparison
• Inform the collector about recent immunoglobulin infusions, chemotherapy, or biologic therapies