INSULIN RECEPTOR ANTIBODY

The INSULIN RECEPTOR ANTIBODY test detects autoantibodies directed against the insulin receptor (IRAb) in a patient’s blood. These antibodies can block or stimulate insulin receptor function, leading to severe insulin resistance or, less commonly, episodic hypoglycaemia; the assay is typically performed on serum using standardized immunoassay techniques. Identifying IRAb is important because it distinguishes autoimmune (type B) insulin resistance from other causes of poor glycaemic control and directly influences treatment strategy.

This home-collection service in Dubai provides convenient venous blood sampling at your residence with processing in accredited laboratories, supporting timely specialist referral to endocrinologists or immunologists in the UAE. The test is useful for patients with sudden, unexplained loss of glycaemic control despite high insulin doses, those with other autoimmune diseases (for example SLE), or when clinicians suspect antibody-mediated insulin resistance; results help guide immunomodulatory treatment and personalised diabetes management. Typical laboratory turnaround is within a few days depending on the referral lab; always review results with your treating physician.

• Insulin Receptor Antibody (IRAb)
• Antibody Titre / Concentration (units per mL)
• Qualitative Result (Positive / Negative / Indeterminate)

• Rapid onset severe insulin resistance requiring very high insulin doses
• Unexplained hyperglycaemia despite adherence to therapy
• New or worsening glycaemic control in patients with known autoimmune disease (e.g., SLE)
• Atypical hypoglycaemic episodes suggestive of antibody-mediated receptor activation
• Before or during consideration of immunosuppressive therapy for suspected type B insulin resistance

• Home venous sample collection across Dubai for patient convenience
• Accurate detection of autoimmune insulin resistance to aid diagnosis
• Supports timely specialist referral and targeted immunotherapy decisions
• Results suitable for use by UAE endocrinologists and immunologists
• Reduces need for hospital visit and speeds personalised diabetes management

• At-home venous blood sample collection by trained phlebotomist
• No fasting usually required unless otherwise instructed by clinician
• Inform the team if you are on immunosuppressants, recent IVIG, or plasmapheresis
• Provide clinical history and current medications to assist interpretation